Four-Piston Diaphragm Pumps

Low-Pulsation, Low-Shear Four-Piston Diaphragm Pump Technology for Biopharmaceutical Applications

Four-Piston Diaphragm Pumps provide gentle, low-shear, and contamination-free fluid transfer for critical biopharmaceutical and laboratory applications.

Available TC Series Models

The TC Series covers a range of four-piston diaphragm pump models designed for different flow capacities and bioprocess requirements.

The TC Series is primarily available as standalone pump heads for integration into process systems, as well as integrated TC-S smart pump systems for laboratory and process development applications.

TC-S models refer to integrated Smart Four-Piston Diaphragm Pumps, in which the pump head and control system are combined into a compact unit primarily intended for laboratory and process development applications.

The integrated control system supports automated pump operation and closed-loop control (including PID control), with the ability to interface with flow and pressure sensors for real-time monitoring and adjustment.

This enables stable and precise control of flow rate and process conditions across a wide range of bioprocess applications, including defined-volume dispensing.

Models are organized from lowest to highest flow capacity, allowing quick and intuitive pump selection.

TC018 quaternary diaphragm pump for biopharmaceutical and laboratory applications

TC018

Flow rate: 0.005–0.3 L/min
Pressure: 10 bar

TC180 quaternary diaphragm pump for biopharmaceutical and laboratory applications

TC180

Flow rate: 0.02–3 L/min
Pressure: 6 bar

TC600 quaternary diaphragm pump for biopharmaceutical and laboratory applications

TC600

Flow rate: 0.1–10 L/min
Pressure: 6 bar

TC1200 quaternary diaphragm pump for biopharmaceutical and laboratory applications

TC1200

Flow rate: 0.2–20 L/min
Pressure: 6 bar

TC2500 quaternary diaphragm pump for biopharmaceutical and laboratory applications

TC2500

Flow rate: 0.4–40 L/min
Pressure: 6 bar

TC5000

Flow rate: 0.8–80 L/min
Pressure: 6 bar

Overview

The Four-Piston Diaphragm Pumps, also known as quaternary diaphragm pumps, are advanced sanitary bioprocess pumping solutions designed for gentle, precise, and contamination-free fluid transfer. They are ideal for shear-sensitive aqueous solutions and biologic products, offering reliable performance with low pulsation, self-priming capability, and risk-free dry running. These pumps are widely used in sanitary fluid handling applications such as biopharmaceutical manufacturing, biotechnology processing, laboratory systems, and other controlled hygienic environments.

The TC series Four-Piston diaphragm pumps are engineered for hygienic and high-precision fluid handling across laboratory, pilot-scale, and production environments. Their sanitary design, stable flow delivery, and low-shear pumping performance make them suitable for critical processes where product integrity, process reliability, and cleanability are essential.

Why Choose TC Series Four-Piston Diaphragm Pumps

The TC Series Four-Piston Diaphragm Pumps are based on proprietary four-piston diaphragm technology developed by Truking Ingenuity with independent intellectual property and patented engineering design.

The pump design is developed with full ownership of the core pump architecture, ensuring reliable product containment, low-shear fluid transfer, and stable long-term performance in critical biopharmaceutical applications.

Sainty Flowtech Inc. is the exclusive distributor in Canada and the United States for Four-Piston Diaphragm Pumps manufactured by Truking Ingenuity Biotechnology Co., Ltd. Truking Ingenuity is a manufacturer of bioprocess equipment, providing integrated solutions for biological separation and purification for global biopharmaceutical applications.

Key Technical Advantages

Core Design & Structural Differentiation

  • PTFE diaphragms providing high pressure resistance and superior chemical compatibility 
  • TC018 to TC1200 pump heads withstand up to 10 bar instantaneous pressure shock 
  • Ball-driven transmission design for improved efficiency and higher torque capability 
  • Validated for over 50 SIP sterilization cycles at 121 °C for 30 minutes under controlled conditions 

Process & Operational Benefits

  • For gentle, low-pulsation and low-shear transfer of sensitive biologics and aqueous solutions
  • Self-priming operation with low pulsation and stable dry-running capability
  • Linear speed-flow relationship with minimal flow reduction under pressure 
  • Hygienic design suitable for CIP and SIP processes 

Learn how the four-piston diaphragm pumping principle enables low shear, low pulsation, self-priming capability, and seal-less hygienic fluid transfer.

Customization & OEM System Integration

The TC Series Four-Piston Diaphragm Pumps can be customized and integrated into a wide range of laboratory, pilot-scale, and production bioprocess systems.

Flexible configuration options allow the pumps to be adapted for OEM equipment manufacturers, system integrators, and specialized biopharmaceutical applications requiring precise, reliable, and hygienic fluid handling.

  • Custom flow range configurations for specific process requirements
  • Integration with chromatography, filtration, and TFF systems
  • OEM equipment integration for bioprocess skids and laboratory instruments
  • Optional control interfaces and automation compatibility
  • Material and wetted part options for different process fluids
  • Compact configurations for laboratory and pilot-scale systems

Typical Industries & Applications

The TC Series Four-Piston Diaphragm Pumps are widely used in biopharmaceutical research, process development, and manufacturing environments requiring gentle, low-shear, and contamination-free fluid transfer.

These pumps support applications ranging from laboratory research and pilot-scale development to full-scale biopharmaceutical manufacturing processes.

Biopharmaceutical Processing

  • Tangential flow filtration (TFF) with low-shear
  • Chromatography and downstream purification
  • Centrifuge feed and aseptic buffer transfer 
  • Sterile and virus filtration

Bioprocess Development

  • Cell culture and protein processing
  • Protein purification
  • Analytical and formulation
  • Vaccine formulation

Laboratory & Pilot Systems

  • Biopharmaceutical laboratory systems
  • Laboratory experiments using diaphragm pumps
  • Pilot-scale bioprocessing systems

Other Sanitary Industries

  • Food and beverage processing
  • Cosmetics and personal care manufacturing
  • Semiconductor industry

Selecting the Right Pump

Choosing the right TC Series Four-Piston diaphragm pump depends on several key factors, including required flow rate, operating pressure, fluid characteristics, cleanability, sterilization requirements, and process scale.

We work closely with customers to evaluate application needs and recommend the optimal pump configuration for reliable, long-term performance.

Scroll to Top